About

Explore Wnt Signaling Pathways

Comprehensive genomic, transcriptomic, and epigenetic data visualization for Wnt family genes. An integrated platform for exploring the Wnt signaling pathway with interactive visualizations across multiple biological contexts and experimental systems.

91
Wnt Genes
7
Data Categories
15+
Data Sources
53
GTEx Tissues
33
TCGA Cancers
1,328
TFs Profiled
Comprehensive Coverage

91 Wnt-pathway genes across eight functional categories:

  • Ligands: all 19 WNTs
  • Frizzled receptors: FZD1–10
  • Co-receptors (LRP5/6) and non-canonical receptors (ROR1/2, RYK)
  • R-spondin axis: RSPO3, LGR4/5/6, RNF43, ZNRF3
  • Secreted antagonists (DKK1–4, SFRP1/2/4/5, FRZB, WIF1, SOST, KREMEN1/2, NOTUM) and secretion machinery (PORCN, WLS)
  • Destruction complex (APC, AXIN1/2, GSK3B, CSNK1A1) with cytoplasmic transducers (CTNNB1, DVL1–3, CSNK1E) and feedback inhibitors (NKD1/2, FRAT1/2)
  • Planar-cell-polarity / Rho axis: VANGL1/2, PRICKLE1/2, CELSR1–3, DAAM1/2, RHOA, RAC1, CDC42
  • Transcription layer (TCF7, TCF7L1/2, LEF1, NLK, TLE1, CTNNBIP1) with canonical target genes (MYC, CCND1)
Multi-Source Integration

Integrates data from major genomics databases:

GTEx (V10) Human Protein Atlas FANTOM5 TCGA (33 cancers) UCSC Xena DepMap CELLxGENE Tahoe100m ENCODE ChIP-Atlas ClinVar Human Methylation Atlas MSigDB Ensembl / NCBI
How to Use WntHub
1
Select Gene
Use the sidebar to choose any Wnt pathway gene
2
Explore Tabs
Genomic context, expression, survival, co-expression networks, correlation, and more
3
Ask the AI
Use the floating assistant to query 23K+ Wnt publications in real-time
4
Export
Download figures (SVG/PNG) and data tables (CSV/TSV/XLSX)
AI Research Assistant

Query-driven AI assistant covering both science and site navigation. A custom RAG pipeline searches 23,323 Wnt-pathway publications for biology questions, while a query classifier routes platform questions ("how do I…?", "where do I find…?") to on-site knowledge for instant answers — no literature retrieval needed. Ask about gene function, expression, clinical relevance, pathway interactions, or how to use WntHub itself.

Try (science): "What cancers show high WNT5A expression in single-cell data?"
Try (site): "Where can I find ClinVar variants and how do I export the table?"

Ungureanu Lab · Precision Oncology · University of Oulu

AI-Generated Gene Summary

Select a gene from the sidebar to view AI-generated summaries across genomic, expression, pathway, functional, and clinical dimensions

Single Cell RNA Expression - CELLxGENE

Select a gene and tissue to view expression data

Single Cell RNA Expression - Tahoe100m

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Tahoe100m Detailed Expression Data

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